The music ministry of First Presbyterian allows children, youth and adults opportunities to express God's love and grace through the musical arts. Choirs for children ages 4 through adults meet weekly and lead in worship and special services throughout the year.

The Carolyn Reynolds Fisher pipe organ was built by the B. Rule & Company in 2002 and has added a new dimension to worship and in concert. The First Presbyterian Concert Series presents nationally known artists free of charge to the Columbia community. An annual Lenten noontime series features area artists in concert as well.